View abstract data
Abstract title Phylogenetic diversification and developmental implications of poly-(R)-3-hydroxyalkanoate gene cluster assembly in prokaryotes
Author Gurusamy Kutralam-Muniasamy, CINVESTAV-IPN, Mexico D.F., Mexico (Presenting author)
Co-author(s) Juan Corona-Hernandez, CINVESTAV-IPN, Mexico D.F., Mexico
Ravi-Kumar Narayanasamy, CINVESTAV-IPN, Mexico D.F., Mexico
Rodolfo Dr. Marsch, CINVESTAV-IPN, Mexico D.F., Mexico
Fermín Dr. Pérez-Guevara, CINVESTAV-IPN, Mexico D.F., Mexico
Topic 19 Evolution of gene expression regulation
Abstract text

Many polyhydroxyalkanoates (PHAs) system genes, such as phaC, phaA, phaB, phaR, phaP, and phaZ, are often found to be organized in the form of operon-like clusters. In this study, a genome survey was performed to identify such clustered PHA systems from among 256 prokaryotic organisms. This data was then used to generate a comprehensive 16S rDNA species tree depicting the phylogenetic distribution of the observed clusters with diverse gene arrangements. In addition, the gene occurrences and physical linkages between PHA system genes were quantitatively estimated. From this, we identified a centrally connected hub gene, i.e., the phaC gene of PHA. Furthermore, a comparative investigation was also performed between the clusters of PHA and glycogen, which decoded the role of the hub gene in the cluster organization of both systems. Together, these findings suggest that the highly connected hub gene might contribute substantively towards the organization and maintenance of the gene network connectivity in the clusters, particularly in the storage reserve systems.