Scientific Program
 
Scientific ProgramSearch Abstract
 
Session
 
Chronic myeloid leukemia - Clinical
Date: Saturday, 06 June 2009
Time:18:00-19:15
Room:
 
18:00-19:15
THERAPY WITH IMATINIB IN ELDERLY CML PATIENTS (=65 YEARS) IS WELL TOLERATED BUT CYTOGENETIC AND MOLECULAR REMISSIONS SEEM TO BE ACHIEVED LATER COMPARED TO YOUNGER PATIENTS 0625
Pletsch, Nadine, Lauseker, M., Saussele, S., Leitner, A., Jung-Munkwitz, S., Müller, M.C., Haferlach, C., Schlegelberger, B., Ehninger, G., Fischer, T., Hossfeld, D.K., Kolb, H.J., Krause, S.W., Nerl, C., Pralle, H., Gratwohl, A., Tobler, A., Heimpel, H., Balleisen, L., Einsele, H., Ho, A.D., Falge, C., Hänel, M., Pfreundschuh, M., Kanz, L., Stegelmann, F., Köhne, C., Kremers, S., Spiekermann, K., Berdel, W., Waller, C.F., Bentz, M., Pfirrmann, M., Hochhaus, A., Hehlmann, R., Hasford, J. (Mannheim, Germany)
 
18:00-19:15
SOKAL SCORE AND RESPONSE TO IMATINIB IN EARLY CHRONIC PHASE CML: THE GIMEMA CML WORKING PARTY EXPERIENCE ON 559 PATIENTS 0626
Baccarani, Michele, Rosti, Gianantonio, Castagnetti, Fausto, Palandri, Francesca, Gugliotta, Gabriele, Ferrara, Felicetto, Gozzini, Antonella, Pulini, Stefano, Montefusco, Enrico, Sica, Simona, Turri, Diamante, Ferrero, Dario, Musolino, Caterina, Bocchia, Monica, Radaelli, Franca, Martinelli, Giovanni, Breccia, Massimo, Pane, Fabrizio, Saglio, Giuseppe (Bologna, Italy)
 
18:00-19:15
NILOTINIB IN CHRONIC MYELOID LEUKEMIA PATIENTS IN CHRONIC PHASE (CML-CP) WITH IMATINIB RESISTANCE OR INTOLERANCE: 24-MONTH FOLLOW-UP RESULTS OF A PHASE 2 STUDY 0627
Kantarjian, Hagop, Giles, Francis, Bhalla, Kapil, Pinilla, Javier, Larson, Richard, Gattermann, Norbert, Ottmann, Oliver, Wang, Jim, Gallagher, Neil, Baccarani, Michele, Le Coutre, Philipp (Houston, United States of America)
 
18:00-19:15
SUBOPTIMAL RESPONSE TO IMATINIB 400 MG DAILY FOR CHRONIC MYELOID LEUKEMIA IN EARLY CHRONIC PHASE: A GIMEMA CML WP ANALYSIS OF 423 CONSECUTIVE PATIENTS 0628
Castagnetti, Fausto, Gugliotta, Gabriele, Breccia, Massimo, Sartor, Donatella, Cavazzini, Francesco, Rupoli, Serena, Pregno, Patrizia, Bruno, Martino, Palandri, Francesca, Amabile, Marilina, Testoni, Nicoletta, Marzocchi, Giulia, Poerio, Angela, Iacobucci, Ilaria, Martinelli, Giovanni, Saglio, Giuseppe, Pane, Fabrizio, Baccarani, Michele, Rosti, Gianantonio (Bologna, Italy)
 
18:00-19:15
THE ORALLY ACTIVE AURORA KINASE A INHIBITOR MLN8237 HAS POTENT ACTIVITY IN PRECLINICAL MODELS OF RESISTANT CHRONIC MYELOID LEUKEMIA AND SIGNIFICANTLY INCREASES THE EFFICACY OF NILOTINIB 0629
Kelly, Kevin, Swords, Ronan, Nawrocki, Steffan, Mahalingam, Devalingam, Medina, Ernest, Smith, Sabrina, Padmanabhan, Swaminathan, Ecsedy, Jeffrey, Giles, Francis J., Carew, Jennifer (San Antonio, United States of America)
 
18:00-19:15
FINAL SAFETY ANALYSIS OF 1,793 CML PATIENTS FROM ENACT (EXPANDING NILOTINIB ACCESS IN CLINICAL TRIALS) STUDY IN ADULT PATIENTS WITH IMATINIB-RESISTANT OR –INTOLERANT CHRONIC MYELOID LEUKEMIA (CML) 0630
Nicolini, Franck, Alimena, Giuliana, Al-Ali, Haifa-Kathrin, Turkina, Anna, Shen, Zhixiang, Jootar, Saengsuree, Smith, Graeme, De Souza, Carmino, Wang, Jim, Berton, Myriam, Szczudlo, Tomek, Rizzieri , David (Lyon, France)
 
18:00-19:15
NILOTINIB IN CHRONIC MYELOID LEUKEMIA PATIENTS IN ACCELERATED PHASE (CML-AP) WITH IMATINIB RESISTANCE OR INTOLERANCE: 24-MONTH FOLLOW-UP RESULTS OF A PHASE 2 STUDY 0631
Hochhaus, Andreas, Giles, Francis, Apperely, Jane, Ossenkoppele, Gert, Wang, Jim, Gallagher, Neil, Baccarani, Michele, Cortes, Jorge, Kantarjian, Hagop, Le Coutre, Philipp (Mannheim, Germany)
 
18:00-19:15
AGE HAS NO IMPACT ON OUTCOME OF EARLY CHRONIC PHASE, PH-POS CML, IMATINIB TREATED PATIENTS: A NATIONWIDE ANALYSIS ON 559 CASES OF THE GIMEMA CML WP 0632
Gugliotta, Gabriele, Castagnetti, Fausto, Amabile, Marilina, Testoni, Nicoletta, Palandri, Francesca, Iacobucci, Ilaria, Soverini, Simona, Luatti, Simona, Breccia, Massimo, Specchia, Giorgina, Intermesoli, Tamara, Radaelli, Franca, Abruzzese, Elisabetta, Usala, Emilio, Saglio, Giuseppe, Martinelli, Giovanni, Pane, Fabrizio, Baccarani, Michele, Rosti, Gianantonio (Bologna, Italy)
 
18:00-19:15
EXPANDING NILOTINIB ACCESS IN CLINICAL TRIALS (ENACT) STUDY IN ADULT PATIENTS (PTS) WITH IMATINIB-RESISTANT OR –INTOLERANT CHRONIC MYELOID LEUKEMIA (CML): SUBGROUP ANALYSIS OF PATIENTS WHO FAILED PRIOR DASATINIB THERAPY 0633
Nicolini, Franck, Alimena, Giuliana, Al-Ali, Haifa-Kathrin, Turkina, Anna, Shen, Zhixiang, Jootar, Saengsuree, Smith, Graeme, Conchon, Monika, Wang, Jim, Berton, Myriam, Szczudlo, Tomek, Rizzieri , David (Lyon, France)
 
18:00-19:15
RELEASE OF INTRACELLULAR CALCIUM PRIMES CHRONIC MYELOID LEUKAEMIA CELLS FOR TYROSINE KINASE INHIBITOR (TKI)-INDUCED APOPTOSIS 0634
Forchap, Sylvia, Pirmohamed, Munir, Clark, Richard (Liverpool, United Kingdom)
 
18:00-19:15
A SHORT (12M) IFNA/IMATINIB COMBINED THERAPY CAN SECURE LONG TERM MAINTENANCE OF IMATINIB INDUCED CYTOGENETIC REMISSION AFTER DISCONTINUATION OF IMATINIB IN CML PATIENTS WITHOUT MOLECULAR REMISSION 0635
Hardan, Izhar, Stemmer, SM, Amariglio, N, Koren-Michowitz , M, Levi , I, Shimoni, A, Binenbaum, Y, Ben-Yehuda , D, Bennett, M, Rechavi, G, Nagler, A (Tel-Hashomer, Israel)
 
18:00-19:15
RESPONSE TO NILOTINIB IS SIMILAR IN IMATINIB-RESISTANT CHRONIC MYELOID LEUKEMIA PATIENTS IN ACCELERATED PHASE (CML-AP) WITH AND WITHOUT BCR-ABL MUTATIONS EXCEPT E255K/V, Y253H, AND F359C/V 0636
Martinelli, Giovanni, Kim, Dong-Wook, Saglio, Giuseppe, Branford, Susan, Erben, Philip, Gottardi, Enrico, Beppu, Lan, Haque, Ariful, Shou, Yaping, Woodman, Richard, Soverini, Simona, Kantarjian, Hagop, Hughes, Tim, Hochhaus, Andreas, Radich, Jerald (Bologna, Italy)
 
18:00-19:15
A STUDY OF PLASMA LEVELS OF IMATINIB AND ITS BIOACTIVE METABOLITE CGP-74588 REVEALS NO CORRELATION WITH SUBSEQUENT CLINICAL OUTCOME IN IMATINIB-TREATED CHRONIC MYELOID LEUKAEMIA 0637
Davies, Andrea, Hayes, Alison, Giannoudis, Athina, Lucas, Claire, Knight, Katy, Watmough, Sarah, Pirmohamed, Munir, Clark, Richard (Liverpool, United Kingdom)
 
18:00-19:15
DASATINIB IN THE TREATMENT OF CHRONIC PHASE CML PATIENTS AGED > 60 YEARS RESISTANT/INTOLERANT TO IMATINIB 0638
Latagliata, Roberto, Breccia, Massimo, Stagno, Fabio, Luciano, Luigiana, Gozzini, Antonella, Annunziata, Mario, De Matteis, Silvia, Albano, Francesco, Ulisciani, Stefano, Pregno, Patrizia, Pacilli, Matteo, Abruzzese, Elisabetta, Martino, Bruno, Tiribelli, Mario, Russo Rossi, Antonella, Sica, Simona, Vitolo, Umberto, Montefusco, Enrico, Rege Cambrin, Giovanna, Ferrara, Felicetto, Santini, Valeria, Pane, Fabrizio, Di Raimondo, Francesco, Alimena, Giuliana (Rome, Italy)
 
18:00-19:15
EFFICACY OF NILOTINIB AFTER IMATINIB FAILURE IN PH-POSITIVE CHRONIC MYELOID LEUKEMIA: IMPACT OF ADDITIONAL CHROMOSOMAL ABERRATIONS AND FREQUENCY OF BCR-ABL POINT MUTATIONS 0639
Kim, Theo, Türkmen, Seval, Schwarz, Michaela, Daniel, Peter, Dörken, Bernd, Le Coutre, Philipp (Berlin, Germany)
 
18:00-19:15
THE ONCOGENIC KINASE BCR-ABL DIRECTLY REGULATES SPLICING EVENTS OF BCLX THROUGH A QUATERNARY COMPLEX COORDINATED BY NCK-BETA AND SAM-68 ADAPTER PROTEINS 0640
Bracco, Enrico, Rosso, Valentina, Mussino , Stefano, Arruga, Francesca, Carturan , Sonia, Messa, Francesca, Panuzzo, Cristina, Lo Iacono, Marco, Nicoli, Paolo, Messa, Emanuela, Rotolo , Antonella, Spagna, Marco, Morotti, Alessandro M.D., Balbo, Alessandra PhD, Iacobucci I., Ilaria, Martinelli , Giovanni, Cilloni, Daniela MD, PhD, Saglio, Giuseppe MD, PhD (Orbassano (TO), Italy)
 
18:00-19:15
COMPARATIVE IN VITRO CELLULAR DATA ALONE IS INSUFFICIENT TO GUIDE CHOICE OF BCR-ABL INHIBITOR TO TREAT IMATINIB-RESISTANT CHRONIC MYELOID LEUKEMIA (CML) 0641
Laneuville, Pierre, DiLea, Clifford, Mestan, Jürgen, Yin, Ophelia, Manley, Paul (Quebec, Canada)
 
18:00-19:15
DYNAMICS OF CYTOGENETIC AND MOLECULAR RESPONSE TO NILOTINIB IS SIMILAR IN IMATINIB-RESISTANT CHRONIC MYELOID LEUKEMIA PATIENTS IN CHRONIC PHASE (CML-CP) WITH AND WITHOUT BCR-ABL MUTATIONS EXCEPT E255K/V, Y253H, AND F359C/V 0642
Saglio, Giuseppe, Hochhaus, Andreas, Martinelli, Giovanni, Gottardi, Enrico, Soverini, Simona, Branford, Susan, Müller, Martin, Beppu, Lan, Haque, Ariful, Shou, Yaping, Woodman, Richard, Kantarjian, Hagop, Radich, Jerald, Hughes, Tim, Kim, Dong-Wook (Orbassano-torino, Italy)
 
18:00-19:15
LONG-TERM SURVIVAL OF PATIENTS WITH LATE CHRONIC PHASE PH-POSITIVE CHRONIC MYELOID LEUKEMIA RECEIVING TYROSINE KINASE INHIBITOR THERAPY AFTER INTERFERON FAILURE 0643
Turkina, Anna G., Stakhina , Olga (P), Gusarova , Galina, Zakharova , Elena, Chelysheva , Ekaterina, Vinogradova , Olga, Kolosheinova , TI, Goryacheva , CR, Kolosova , LYu, Domracheva , EV, Zakharova , AV, Abakumov , EM, Kulikov , Sergei, Khoroshko , ND (Moscow, Russian Federation)
 
18:00-19:15
PREGNANCY AMONG THE PATIENTS WITH CHRONIC MYELOID LEUKEMIA ON IMATINIB THERAPY 0644
Chelysheva, Ekaterina, Turkina, A.G., Gusarova, G.A., Kolosheinova, T.I., Sokolova, M.A., Khoroshko, N.D., Pepelyaeva, V.M., Gavrilova, L.V. (Moscow, Russian Federation)